University of Oklahoma Health Sciences Center

Emergency Medicine

Intranasal Naloxone for Opioid Overdose

Author/s:

Jessica L Taylor, Karen E Lasser

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In 2021, opioid overdose deaths exceeded 80 000 in the US.1 Naloxone, a competitive opioid receptor antagonist that reverses symptoms of opioid intoxication and overdose by displacing opioids from μ-opioid receptors, is a safe and effective medication for preventing opioid overdose death. Naloxone meets US Food and Drug Administration (FDA) criteria for approval without a prescription: its benefits outweigh risks, it treats a condition that can be identified by people in the community, it has a low potential for misuse, and it can be labeled to facilitate correct administration.

Keywords

Emergency Medicine Substance Use addiction opioids public health Toxicology Naloxone

Can family physicians accurately screen for AAA with point-of-care ultrasound?

Author/s:

Cade, N., Granath, B., Nether, J. O., Safranek, S.

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EVIDENCE-BASED ANSWER:
LIKELY YES. POINT-OF-CARE ULTRASOUND (POCUS) SCREENING FOR ABDOMINAL AORTIC ANEURYSM (AAA) BY NONRADIOLOGIST PHYSICIANS IS 98% SENSITIVE AND 99% SPECIFIC, COMPARED WITH IMAGING PERFORMED BY RADIOLOGISTS (STRENGTH OF RECOMMENDATION [SOR]: B, META-ANALYSIS OF DIAGNOSTIC ACCURACY STUDIES MOSTLY INVOLVING EMERGENCY MEDICINE PHYSICIANS). EUROPEAN FAMILY PHYSICIANS DEMONSTRATED 100% CONCORDANCE WITH RADIOLOGIST READINGS (SOR: C, VERY SMALL SUBSEQUENT DIAGNOSTIC ACCURACY STUDIES).