University of Oklahoma Health Sciences Center

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Author/s:

Ahmad, maud, Sniderman, Allan D., Hegele, Robert A.

Date Added:

October 2, 2023

Journal/Publication:

CMAJ

Publisher:

CMA

Publication Date:

August 28, 2023

Issue:

Volume:

195

URL:

Apolipoprotein B in cardiovascular risk assessment

Type:

Meta-analyses, Reviews, and Guidelines

Format:

Article

DOI (1):

10.1503/cmaj.230048

PMID (1):

37640407

Keywords

Cardiovascular Diseases

heart disease

MeSH

Cardiovascular Diseases* / epidemiology

Apolipoproteins

risk factors

RPR Commentary

Apo B may be a more accurate and convenient measure of CAD event risk than LDL cholesterol. James W. Mold, MD, MPH

Abstract

Apolipoprotein (apo) B measurement is a recommended alternative to low-density lipoprotein cholesterol (LDL-C)
The 2021 Canadian Cardiovascular Society guideline on dyslipidemia recommends that physicians may use levels of either non-high-density lipoprotein cholesterol (HDL-C) or apo B instead of LDL-C for screening and targets of treatment.1 Non-HDL-C represents total cholesterol minus cholesterol from HDL particles; apo B represents the total number of atherogenic particles, since 1 apo B molecule is found on each LDL, very low–density lipoprotein, intermediate-density lipoprotein and lipoprotein(a) particle.2

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