University of Oklahoma Health Sciences Center

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Author/s:

Lolita Alocer Alkureishi, Sai R. Nimmagadda, Joseph R. Hageman

Date Added:

October 9, 2026

Journal/Publication:

Pediatric Annals

Publisher:

SLACK Incorporated

Publication Date:

October 1, 2026

Issue:

Volume:

Pages:

e374-377

URL:

Beyond Avoidance: Omalizumab and the Evolving Care of Pediatric Food Allergy

Type:

Meta-analyses, Reviews, and Guidelines

Format:

Article

DOI (1):

https://doi.org/10.3928/19382359-20260908-02

Keywords

Pediatric Food Allergies

omalizumab

children

MeSH

Omalizumab* / therapeutic use

Food Hypersensitivity* / diagnosis

allergens

RPR Commentary

RPR Commentary: Advice regarding how to evaluate and manage food allergies in children. James W. Mold, MD, MPH

Abstract

Food allergy is familiar territory in primary care, but the therapeutic landscape is changing quickly. For years, our conversations with families centered on avoidance, label reading, emergency action plans, and ready access to epinephrine. Those remain essential. Yet, newer therapies now offer something different: the possibility of increasing the amount of allergen needed to trigger a reaction and thereby reducing some of the risk associated with accidental exposure. The recent randomized clinical trial by Wood et al.1 brings that shift into especially sharp focus. In patients with multiple food allergies, continued omalizumab treatment was more successful than omalizumab-facilitated multiallergen oral immunotherapy in the intention-to-treat analysis, largely because adverse events and treatment discontinuations limited completion of oral immunotherapy.