University of Oklahoma Health Sciences Center

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Author/s:

Chambers, Laura C., Hallowell, benjamin D., Zullo, Andrew R.

Date Added:

October 8, 2023

Journal/Publication:

JAMA Netw Open

Publisher:

AMA

Publication Date:

September 18, 2023

Issue:

Volume:

URL:

Buprenorphine Dose and Time to Discontinuation Among Patients With Opioid Use Disorder in the Era of Fentanyl

Type:

Clinical Research Results

Format:

Article

DOI (1):

10.1001/jamanetworkopen.2023.34540

PMID (1):

37721749

Keywords

cohort study

Opiod use disorder

fentanyl

MeSH

Buprenorphine* / therapeutic use

Fentanyl / therapeutic use

cohort studies

retrospective studies

RPR Commentary

Consider somewhat higher doses of buprenorphine than recommended in patients using or at risk for using fentanyl. James W. Mold, MD, MPH

Abstract

Question: Are higher doses of buprenorphine treatment for opioid use disorder associated with improved retention in treatment when use of fentanyl (vs heroin) is more prevalent?

Findings: In this cohort study of 6499 patients initiating buprenorphine treatment between 2016 and 2020, those prescribed the recommended daily dose (16 mg) were at significantly greater risk of treatment discontinuation within 180 days than those prescribed a higher dose (24 mg).

Meaning: The results of this study suggest that the value of higher buprenorphine doses than currently recommended needs to be considered for improving retention in treatment.

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