University of Oklahoma Health Sciences Center

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Author/s:

Barouch, D. H.

Date Added:

September 8, 2022

Journal/Publication:

The New England Journal of Medicine

Publisher:

Massachusetts Medical Society

Publication Date:

August 31, 2022

URL:

Covid-19 Vaccines — Immunity, Variants, Boosters

Type:

Meta-analyses, Reviews, and Guidelines

Format:

Article

DOI (1):

10.1056/NEJMra2206573

PMID (1):

36044620

Keywords

United States

Biomedical Research

vaccines

Pandemics

Immunity

MeSH

Vaccination Hesitancy

RPR Commentary

A summary of the current state of knowledge regarding COVID vaccines and emerging COVID variants. James W. Mold, MD, MPH

Abstract

The coronavirus disease 2019 (Covid-19) pandemic has claimed an estimated 15 million lives, including more than 1 million lives in the United States alone. The rapid development of multiple Covid-19 vaccines has been a triumph of biomedical research, and billions of vaccine doses have been administered worldwide. Challenges facing the Covid-19 vaccine field include inequitable vaccine distribution, vaccine hesitancy, waning immunity, and the emergence of highly transmissible viral variants that partially escape antibodies. This review summarizes the current state of knowledge about immune responses to Covid-19 vaccines and the importance of both humoral and cellular immunity for durable protection against severe disease.

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