University of Oklahoma Health Sciences Center

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Author/s:

Ruchi Singla, Megan C Elios, Andrew M Davis

Date Added:

September 16, 2024

Journal/Publication:

JAMA

Publisher:

American Medical Association

Publication Date:

September 11, 2024

URL:

Evaluation of Suspected Antibiotic Allergies

Type:

Meta-analyses, Reviews, and Guidelines

Format:

Article

DOI (1):

10.1001/jama.2024.14143

PMID (1):

39259567

Keywords

Anaphylaxis

antibiotics

antibiotic allergies

MeSH

Anaphylaxis

Immune Checkpoint Inhibitors

anti-bacterial agents

Anti-Bacterial Agents / adverse effects

Drug Hypersensitivity

RPR Commentary

RPR Commentary: A CPG for management of patients with a history of allergy to antibiotics. James W. Mold, MD, MPH

Abstract

Antibiotic-associated adverse drug reactions are often mild (eg, nausea or diarrhea) and typically occur 1 to 6 hours after drug exposure. IgE-mediated reactions cause urticaria, angioedema, bronchospasm, or, in severe cases, anaphylaxis. Cell-mediated delayed hypersensitivity can occur over days to weeks, most commonly as benign cutaneous morbilliform eruptions, although more severe manifestations, such as Stevens-Johnson syndrome, may occur.

The guideline provides evidence-based recommendations for evaluating possible drug allergy in nonsteroidal anti-inflammatory drugs, chemotherapies, immune checkpoint inhibitors, biologic agents, and excipients (inactive substances formulated with pharmaceuticals). This JAMA Clinical Guidelines Synopsis focuses on practice recommendations for antibiotic allergy evaluation.

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