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Lack of evidence for cannabis in adults with chronic neuropathic pain

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Author/s: 
McAvoy, Brian R.
Date Added: 
December 4, 2018
Journal/Publication: 
Pearls
Issue: 
597
Type: 
Meta-analyses, Reviews, and Guidelines
Keywords 
medical marijuana
cannabis
neuralgia
neuropathic pain
cannabidiol
MeSH 
cannabis
neuralgia
cannabidiol
medical marijuana

RPR Commentary

There is so far no high quality evidence to support the use of cannabinoids for relief of chronic neuropathic pain.

 

 

Abstract

Bottom Line:

There was no high-quality evidence for the efficacy of any CBM (herbal cannabis, plant-derived tetrahydrocannabinol (THC) (dronabinol), synthetic THC (nabilone), plant-derived THC/cannabidiol (CBD) com bination) in any condition with chronic neuropathic pain. The studies were two to 26 weeks long and compared an oromucosal spray with a plant-derived combination of THC and CBD (10 studies), a synthetic cannabinoid mimicking THC (nabilone) (two studies), inhaled herbal cannabis (two studies) and plant-derived THC (dronabinol) (two studies) against placebo (15 studies) and an analgesic (dihydrocodeine) (one study). Herbal cannabis was not different from placebo in reducing pain and the number of people who dropped out due to side effects. Some adverse events (particularly somnolence or sedation, confusion, psychosis) might limit the clinical usefulness of cannabis-based medicines.

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