University of Oklahoma Health Sciences Center

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Author/s:

Sarah E. Messmer, Molly M. Perri, Andrew M. Davis

Date Added:

January 28, 2026

Journal/Publication:

JAMA

Publication Date:

January 21, 2026

URL:

Management of Opioid Use Disorder

Type:

Meta-analyses, Reviews, and Guidelines

Format:

Article

DOI (1):

10.1001/jama.2025.25464

Keywords

Opiod use disorder

Opiates

opiod misuse

addiction

MeSH

Analgesics

opioid

opioid-related disorders

Opiates

Addiction

Addiction Disorders

RPR Commentary

A concise summary of guideline recommendations for helping patients with opioid use disorder. James W. Mold, MD, MPH

Abstract

Opioid use disorder is a chronic disease characterized by a maladaptive pattern of opioid use despite negative consequences. In the US, nearly 75 000 overdose deaths occurred in 2023, a 10-fold increase from 1999.1 However, only 1 in 4 US adults eligible for MOUD received it in 2022.2 The 2024 CRISM guideline outlines evidence-based OUD management that can be implemented by clinicians with or without specialized MOUD training for patients aged 18 years or older.3 It does not address withdrawal induction protocols, scheduling of opioid agonist therapies, or urine drug testing.