University of Oklahoma Health Sciences Center

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Author/s:

Lin, Dan-Yu, Huang, Shuaiqi, Abi Fadel, Francois

Date Added:

October 4, 2023

Journal/Publication:

JAMA Network Open

Publisher:

AMA

Publication Date:

September 21, 2023

Issue:

Volume:

URL:

Nirmatrelvir or Molnupiravir Use and Severe Outcomes From Omicron Infections

Type:

Clinical Research Results

Format:

Article

DOI (1):

10.1001/jamanetworkopen.2023.35077

PMID (1):

37733342

Keywords

COVID-19

Ritonavir

Molnupiravir

COVID-19 variants

MeSH

COVID-19* / epidemiology

COVID-19 Vaccines

COVID-19 Drug Treatment

RPR Commentary

High risk outpatients with COVID (omicron type) appear to benefit from either molnupiravir or nirmatrelvir. James W. Mold, MD, MPH

Abstract

Question: What outcomes are associated with ritonavir-boosted nirmatrelvir or molnupiravir use for outpatient treatment of SARS-CoV-2 Omicron subvariants, particularly BQ.1.1 and XBB.1.5, in high-risk individuals?

Findings: In a cohort study of 68 867 patients who received a diagnosis of COVID-19 at Cleveland Clinic from April 1, 2022, to February 20, 2023, and who were at high risk of progressing to severe COVID-19, both nirmatrelvir and molnupiravir use were significantly associated with reductions in hospitalization and death. The association was observed across subgroups defined by age, race and ethnicity, date of diagnosis, vaccination status, previous infection status, and coexisting conditions.

Meaning: These findings suggest that both nirmatrelvir and molnupiravir can be used to treat nonhospitalized patients who are at high risk of progressing to severe COVID-19.

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