University of Oklahoma Health Sciences Center

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Author/s:

Petty, L. A., Malani, P. N.

Date Added:

May 10, 2022

Journal/Publication:

Journal of the American Medical Association

Publisher:

American Medical Association

Publication Date:

April 25, 2022

URL:

Oral Antiviral Medications for COVID-19

Type:

Patient Education Materials

Format:

Poster

DOI (1):

10.1001/jama.2022.6876

Keywords

medication

Antiviral

COVID-19

treatment

MeSH

PF-07321332 and ritonavir drug combination

RPR Commentary

Information for patients on the appropriate use of oral antivirals for COVID. James W. Mold, MD, MPH

Abstract

Twonewantiviralmedications, ritonavir-boostednirmatrelvir (Paxlovid,
ie, nirmatrelvir-ritonavir) and molnupiravir (Lagevrio), are currently
available in theUS underemergency useauthorization. These 2 drugs
areauthorized for treatmentofpatientswithmild tomoderateCOVID19 who are not currently hospitalized but are at high risk of developingseveredisease.Nirmatrelvir-ritonavirandmolnupiravirareapproved
for use only within 5 days of onset of COVID-19 symptoms.
Nirmatrelvir-ritonavir andmolnupiravir should be considered for
patients with symptoms of COVID-19 who test positive for SARSCoV-2 and either are an older adult (aged 65 years or older) or are
aged 12 years or older with an underlying condition that increases
risk of severe outcomes of COVID-19 (such as cancer, heart disease,
diabetes, and obesity).

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