University of Oklahoma Health Sciences Center

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Author/s:

Emily P. Marogi, Lisa Dubrofsky, Robert J. Weber

Date Added:

September 9, 2026

Journal/Publication:

JAMA Intern Med

Publisher:

The American Medical Association

Publication Date:

September 8, 2026

Pages:

E1-E2

URL:

Primary Aldosteronism

Type:

Meta-analyses, Reviews, and Guidelines

CME Credits:

Format:

Article

DOI (1):

doi: 10.1001/jamainternmed.2026.4155

Keywords

primary aldosteronism

Adrenal Glands

Endocrinology

MeSH

Aldosterone

Hyperkalemia

adrenal

RPR Commentary

RPR Commentary: A review of primary aldosteronism, a treatable condition present in approximately 6% in adult primary care patients to 29% of patients with treatment-resistant hypertension. James W. Mold, MD, MPH

Abstract

Primary aldosteronism (PA) is an endocrine disorder that results from aldosterone overproduction by the adrenal glands, independent of physiological stimuli (hyperkalemia or renin). Symptomatic PA can cause hypertension and hypokalemia, but PA exists across a spectrum of severity from subclinical disease to treatment-resistant hypertension and from normokalemia to severe hypokalemia. PA remains underdiagnosed despite the fact that targeted therapies can reduce morbidity and mortality.1,2 This Clinical Insights article provides clinicians with a practical approach to diagnosing and managing PA.

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