University of Oklahoma Health Sciences Center

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Author/s:

Bhat, Chirag, Rosenberg, Hans, James, Daniel

Date Added:

October 3, 2023

Journal/Publication:

CMAJ

Publisher:

CMA

Publication Date:

September 18, 2023

Issue:

Volume:

195

URL:

Topical nonsteroidal anti-inflammatory drugs

Type:

Meta-analyses, Reviews, and Guidelines

Format:

Article

DOI (1):

10.1503/cmaj.230578

PMID (1):

37722741

Keywords

Inflammation

NSAID

MeSH

Anti-Inflammatory Agents

Non-Steroidal*

RPR Commentary

A concise review of the evidence supporting the effectiveness and safety of topical NSAIDS. James W. Mold, MD, MPH

Abstract

Topical nonsteroidal anti-inflammatory drugs (NSAIDs) provide local analgesia and anti-inflammatory effects with minimal systemic uptake
Nonsteroidal anti-inflammatory drugs inhibit the cyclooxygenase enzyme, reducing inflammation and pain. Compared with oral formulations, topical NSAIDs work locally, with systemic uptake limited to around 5%.1 High-quality evidence supports the analgesic role of several topical NSAIDs, including diclofenac and ketoprofen.1 Salicylate-containing rubefacients are excluded from this discussion given their distinct mechanism of action.

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