University of Oklahoma Health Sciences Center

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Author/s:

Fatema Mollah, Mark A Zacharek, Mariel R Benjamin

Date Added:

December 13, 2023

Journal/Publication:

JAMA

Publisher:

American Medical Association

Publication Date:

December 8, 2023

URL:

What Is Alpha-Gal Syndrome?

Type:

Patient Education Materials

Format:

Article

DOI (1):

10.1001/jama.2023.23097

PMID (1):

38064235

Keywords

allergy and clinical immunology

Patient Information

diet

red meat allergy

MeSH

Food Hypersensitivity

RPR Commentary

Information for patients about alpha-gal syndrome. James W. Mold, MD, MPH

Abstract

Alpha-gal syndrome is a type of food allergy to mammalian (red) meat products.

Alpha-gal syndrome is associated with tick bites, most commonly from the Lone Star tick in the US, but also from different types of ticks in other areas of the world. During a bite, a tick injects a type of sugar molecule (galactose-alpha-1,3-galactose), also called alpha-gal, which leads to formation of an antibody. Because alpha-gal is present on cells of most mammals, including cows, pigs, lambs, and goats, when affected individuals eat these animal products, an allergic reaction may occur.

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