This COVID-19 outpatient randomized controlled trials (RCTs) systematic review compares hospitalization outcomes amongst four treatment classes over pandemic period, geography, variants, and vaccine status. Outpatient RCTs with hospitalization endpoint were identified in Pubmed searches through...
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Outpatient randomized controlled trials to reduce COVID-19 hospitalization: Systematic review and meta-analysis
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Statins and cognitive decline in patients with Alzheimer's and mixed dementia: a longitudinal registry-based cohort study
Background
Disturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer’s disease (AD). Lipid-lowering medications could interfere with neurodegenerative processes in AD through cholesterol metabolism or other mechanisms.
Objective
To explore...
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Gold 2023: Highlights for Primary Care
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has issued its 2023 annual report1. Compared with former versions, it has been significantly updated. Here, we summarize the most relevant changes for a Primary Care audience. The complete document can be downloaded for free from...
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Effect of Psychological and Medication Therapies for Insomnia on Daytime Functions: A Randomized Clinical Trial
Importance: Daytime functional impairments are the primary reasons for patients with insomnia to seek treatment, yet little is known about what the optimal treatment is for improving daytime functions and how best to proceed with treatment for patients whose insomnia has not remitted.
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Nonprescription Medications for Adults With Allergic Rhinitis
Nonprescription medications for allergic rhinitis (hay fever) are over-the-counter drugs that treat symptoms such as runny nose, itchy eyes, and sneezing.
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Intranasal Naloxone for Opioid Overdose
In 2021, opioid overdose deaths exceeded 80 000 in the US.1 Naloxone, a competitive opioid receptor antagonist that reverses symptoms of opioid intoxication and overdose by displacing opioids from μ-opioid receptors, is a safe and effective medication for preventing opioid overdose death....
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Eye Infections
Eye infections are an important cause of vision loss worldwide. Patients with these infections are commonly seen by primary care providers, internists, emergency medicine specialists, hospitalists, and ophthalmologists. Each year in the United States alone, conjunctivitis accounts for more than...
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Common Painful Foot and Ankle Conditions: A Review
Importance: Morton neuroma, plantar fasciitis, and Achilles tendinopathy are foot and ankle conditions that are associated with pain and disability, but they can respond to nonoperative treatment.
Observations: Morton neuroma, consisting of interdigital neuronal thickening and fibrosis,...
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Driving Impairment Among Older Adults
Older drivers may have age-related and medical conditions that affect their driving performance.
More than 90% of car crashes are caused by human error. In older adults, age-related changes of decreased vision, cognitive decline, slowed reaction time, and decreased grip strength increase...
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Frontotemporal dementia
Frontotemporal dementia should be considered in adults aged 50–75 years presenting with behavioural or language changes. After Alzheimer disease, it is the second most common cause of dementia among adults younger than 65 years.1 Frontal and temporal lobe degeneration results in behavioural or...
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