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Testosterone Treatment in Middle-Aged and Older Men with Hypogonadism

Author/s: Shalender Bhasin, Peter J Snyder

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In clinical trials involving middle-aged and older men with hypogonadism, testosterone treatment led to improved sexual activity and libido, correction of anemia, and modestly improved energy, mood, and walking ability. (The following key points also refer to findings from clinical...

Keywords/Tags:
testosterone hypogonadism Libido anemia pulmonary embolism

Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation: The ALONE-AF Randomized Clinical Trial

Author/s: Daehoon Kim, MD, Jaemin Shim, MD, Eue-Keun Choi, MD

Importance: Data from randomized clinical trials on a long-term anticoagulation strategy for patients after catheter-based ablation for atrial fibrillation (AF) are lacking.

Objective: To evaluate whether discontinuing oral anticoagulant therapy provides superior clinical outcomes...

Keywords/Tags:
clinical pharmacy and pharmacology Oral Anticoagulation Cardiology atrial fibrillation Rhythm Disorders

Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation

Author/s: Gilles Lemesle, M.D., Ph.D., Romain Didier, M.D., Ph.D., Philippe Gabriel Steg, M.D., Tabassome Simon, M.D., Ph.D., Gilles Montalescot, M.D., Ph.D., Nicolas Danchin, M.D., Christophe Bauters, M.D., Ph.D.

Background: The appropriate antithrombotic regimen for patients with chronic coronary syndrome who are at high atherothrombotic risk and receiving long-term oral anticoagulation remains unknown.

Methods: We conducted a multicenter, double-blind, randomized, placebo-controlled trial in...

Keywords/Tags:
Chronic Coronary Syndrome Oral Anticoagulation aspirin atherothrombotic risk stent implantation

Efficacy and Safety of Seltorexant in Insomnia Disorder: A Randomized Clinical Trial

Author/s: Sofie Mesens, Andrew D Krystal, Rama Melkote, Haiyan Xu, Gahan Pandina, Jay B Saoud, Remy Luthringer, Adam Savitz, Wayne C Drevets

Importance: Existing pharmacological treatments for insomnia have significant limitations.

Objective: To assess the effective dose range, safety, and tolerability of the novel selective orexin-2 receptor antagonist seltorexant in insomnia disorder.

Design, setting, and participants...

Keywords/Tags:
sleep medicine neurology Psychiatry and Behavioral Health Seltorexant Insomnia medications sleep disorders

Venomous Snakes and Snakebites

Author/s: Kevin Lieu, MD, Kathy T. LeSaint, MD, Zhanna Livshits, MD

This JAMA Patient Page describes the venomous snakes found in the US as well as snakebite symptoms, treatment, and prevention.
Keywords/Tags:
Toxicology jama Patient Information Trauma and Injury Emergency Medicine Snake Bites venom

Restless Legs Syndrome in Adult Primary Care

Author/s: Mathur A, Bhat A, Gohar A

Restless Legs Syndrome (RLS) or Willis‑Ekbom Disease is a sensorimotor condition marked by an irresistible need to move the legs, typically accompanied by uncomfortable sensations that peak during periods of rest and disrupt nightly sleep. Early identification in primary care is essential, as...

Keywords/Tags:
Restless Legs Syndrome Dopamine Agonists Sleep Hygiene Sleep Quality Leg quality of life

Adrenal Insufficiency in Adults: A Review

Author/s: Anand Vaidya, James Findling, Irina Bancos

Importance: Adrenal insufficiency is a syndrome of cortisol deficiency and is categorized as primary, secondary, or glucocorticoid induced. Although primary and secondary adrenal insufficiency are rare, affecting less than 279 per 1 million individuals, glucocorticoid-induced adrenal...

Keywords/Tags:
Adrenal Hyperplasia Congenital Acute Disease Hemochromatosis Injections Intramuscular Nausea Vomiting

Cutaneous Melanoma: A Review

Author/s: Urvashi Mitbander Joshi, Mohammed Kashani-Sabet, John M. Kirkwood

Importance: Melanoma, the fifth most common cancer in the US, has increased from 8.8 per 100 000 in 1975 to 28.42 per 100 000 in 2022. Cutaneous melanoma comprises 94% of cases, with 104 960 US cases projected for 2025.

Observations: Cutaneous melanoma presents as a new, changing, or...

Keywords/Tags:
dermatology oncology skin cancer melanoma Targeted and Immune Therapy

Treatment of Atopic Dermatitis

Author/s: Aaron M. Drucker

Not Available
Keywords/Tags:
dermatology atopic dermaitis

Hemorrhoidal Disease: A Review

Author/s: Jean H Ashburn

Importance Hemorrhoidal disease, pathology of the tissue lining of the anal canal, affects approximately 10 million individuals in the US. Hemorrhoidal disease may impair quality of life due to bleeding, pain, anal irritation, and tissue prolapse.

Observations Hemorrhoids are classified...

Keywords/Tags:
Gastroenterology colorectal hepatology

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