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Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults

Author/s: Sophia Zoungas, Rory Wolfe, Chris Moran, Stephen J. Nicholls, Geoffrey C. Cloud, Christopher M. Reid, Andrew M. Tonkin, Lawrence Beilin, Anthony S. Wierzbicki, Trevor T.-J. Chong, Jonathan C. Broder, Andrea J. Curtis, Zachary Flanagan, Ingrid Hopper, Joanne Ryan, Simone Spark, John J. McNeil, Mark R. Nelson

Abstract
Background
The effectiveness and safety of statins for the primary prevention of cardiovascular events and the extension of disability-free survival among older adults remain uncertain.
Methods
We conducted a double-blind, randomized, placebo-controlled trial at...

Keywords/Tags:
Atorvastatin cardiovascular events statins

Astegolimab for chronic obstructive pulmonary disease with frequent exacerbations: pooled analysis of the ALIENTO and ARNASA trials

Author/s: Jadwiga A Wedzicha, Alvar Agustí, Christopher E. Brightling, Peter Calverley, James D. Chalmers, Neil J. Greening, MeiLan K. Han, Divya Mohan, Julie Ng, Papi, Alberto, Nicolas Roche, Rebecca Saenz, Katerina Samara, Ruth Tal-Singer, Claus F. Vogelmeier, Xiaoying Yang, Bartolome R. Celli

Rationale
The efficacy and safety of astegolimab, an anti-ST2 monoclonal antibody, was evaluated in participants with chronic obstructive pulmonary disease (COPD) and frequent exacerbations in the pivotal ALIENTO and ARNASA trials.

Objectives
To report the prespecified pooled...

Keywords/Tags:
Astegolimab pulmonary disease chronic obstructive pulmonary disease ALIENTO trails ARNASA trials

Reliability of Physical Examination Findings in Youths Diagnosed With Pneumonia

Author/s: Shubhada Hooli, Ron Reeder, Lauren Cutler, Laura F Sartori, Geoff Capraro, Amy Y. Cheng, Allison Cator, Matthew J. Lipshaw, Lilliam Ambroggio, Chris A. Rees, Son H. McLaren, Justin Moher, Leah Tzimenatos, Patrick S. Walsh, Chari D. Larsen, Richard M. Ruddy, Samir S. Shah, Nathan Kuppermann, Todd A. Florin

Abstract
Importance Community-acquired pneumonia (CAP) accounts for nearly 2 million pediatric outpatient and 375 000 emergency department (ED) visits annually in the US. Guidelines recommend relying on physical examination findings, not imaging, to diagnose CAP in youths who can be...

Keywords/Tags:
pneumonia youth Physical Examination

Lumbar Belt for Nonspecific Low Back Pain: A Randomized Clinical Trial

Author/s: Laurent Grange, Paul Calmels, Yves-Marie Pers, Guillaume Laustriat, Valerie Wieczorek, Nassima Saih, Mathieu De-Seze, Christelle Nguyen, Camille Daste, Isabelle Fayolle-Minon, Emmanuel Coudeyre, Francois Rannou

Importance Nonspecific low back pain is highly prevalent and disabling. Most current guidelines state that evidence is insufficient to recommend lumbar belts for this condition.

Objective To determine whether a soft and extensible lumbar belt reduces functional disability and pain in...

Keywords/Tags:
Nonspecific Low Back Pain Randomized Clinical Trial Adults

Pelvic Floor Workout For Preventing Stress Unrinary Incontinence in Primiparous Women A Randomized Clinical Trial

Author/s: Lei Gao, Hongmei Zhu, Xiaohui Sun, Shiyan Wang, Bing Xie, Huixin Liu, Wenhui Ren, Jinyu Liang, Xiaoke Tang, Min Zhen, Guizhu Wu, Baoling Qin, Yan Hu, Lingrui Kong, Weipeng Chen, Xiuli Sun, Jianliu Wang

mportance Rehabilitation training methods for stress urinary incontinence (SUI) need to be based on a global postural exercise, involving overall core muscle strength, core stability, and balance of the pelvis and spine. The pelvic floor workout (PEFLOW) program was developed to promote in-...

Keywords/Tags:
stress urinary incontinence Primiparous Women pelvic floor

Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study

Author/s: Ophir Lavon, Wafaa Hamodi, Sameer Kassem

Background: Evidence supporting the use of statins for primary prevention of cardiovascular disease (CVD) in individuals aged ≥ 80 years remains limited. This study aimed to evaluate the long-term clinical benefits and safety of statins for primary prevention in patients aged 80 years and older...

Keywords/Tags:
prevention cardiovascular disease statins

Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study

Author/s: Wafaa Hamodi, Ophir Lavon, Samir Kassem

ABSTRACT Background: Evidence supporting the use of statins for primary prevention of cardiovascular disease (CVD) in individuals aged≥ 80 years remains limited. This study aimed to evaluate the long-term clinical benefits and safety of statins for primary prevention in patients aged 80 years...

Keywords/Tags:
statin therapy Geriatrics cardiovascular disease Adults Aged 80 years or older

Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study

Author/s: Wafaa Hamodi, Ophir Lavon, Samir Kassem

ABSTRACT Background: Evidence supporting the use of statins for primary prevention of cardiovascular disease (CVD) in individuals aged≥ 80 years remains limited. This study aimed to evaluate the long-term clinical benefits and safety of statins for primary prevention in patients aged 80 years...

Keywords/Tags:
statin therapy Geriatrics cardiovascular disease Adults Aged 80 years or older

Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study

Author/s: Wafaa Hamodi, Ophir Lavon, Samir Kassem

ABSTRACT Background: Evidence supporting the use of statins for primary prevention of cardiovascular disease (CVD) in individuals aged≥ 80 years remains limited. This study aimed to evaluate the long-term clinical benefits and safety of statins for primary prevention in patients aged 80 years...

Keywords/Tags:
statin therapy Geriatrics cardiovascular disease Adults Aged 80 years or older

Intranasal Treatments for Children With Sleep-Disordered Breathing: The MIST+ Randomized Clinical Trial

Author/s: Gillian M. Nixon, Deborah Anderson, Alice Baker

Importance: Symptoms of obstructive sleep apnea are common in childhood and associated with significant comorbidity. Surgical treatment with adenotonsillectomy is first-line treatment but medical treatments show potential to improve symptoms and reduce the need for surgery.

Objective: To...

Keywords/Tags:
Sleep Apnea Syndromes sleep apnea Obstructive sleep apnea Polysomnography Mometasone Furoate

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