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Management of Latent Tuberculosis Infection

Author/s: Kim, S., Thal, R., Szwarko, D.

In theUS, approximately 13million people have latent tuberculosis infection (LTBI),definedaspeoplewhoareinfectedwithMycobacterium
tuberculosiswho do not have symptoms and do not transmit the disease.Without treatment, approximately 5% to 10% of immunocompetent personswithLTBI develop...

Keywords/Tags:
prednisone Tuberculin Centers for Disease Control and Prevention, U.S. tuberculosis Infection

Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients

Author/s: Nissen, S. E., Menon, V., Nicholls, S. J., Brennan, D., Laffin, L., Ridker, P., Ray, K. K., Mason, D., Kastelein, J. J. P., Cho, L., Libby, P., Li, N., Foody, J., Louie, M. J., Lincoff, A. M.

Importance: The effects of bempedoic acid on cardiovascular outcomes in statin-intolerant patients without a prior cardiovascular event (primary prevention) have not been fully described.

Objective: To determine the effects of bempedoic acid on cardiovascular outcomes in primary...

Keywords/Tags:
Cardiovascular Diseases stroke drug therapy bempedoic acid statin-intolerant patients

Demystifying breast cancer

Author/s: Wilkinson, A. N.

The first question a patient often asks their FP after receiving a diagnosis of breast cancer (BC) is “What will my treatment be?” This article will help FPs answer this complex question by reviewing multimodal therapy for BC, which is contingent on molecular subtype and stage.
Keywords/Tags:
breast cancer treatment surgery therapy chemotherapy

Screening for Anxiety Disorders in Adults: US Preventive Services Task Force Recommendation Statement

Author/s: US Preventive Services Task Force, Barry, M. J., Nicholson, W. K., Silverstein, M., Coker, T. R., Davidson, K. W., Davis, E. M., Donahue, K. E., Jaén, C. R., Li, L., Ogedegbe, G., Pbert, L., Roa, G., Ruiz, J. M., Stevermer, J., Tsevat, J., Underwood, S. M., Wong, J. B.

Importance: Anxiety disorders are commonly occurring mental health conditions. They are often unrecognized in primary care settings and substantial delays in treatment initiation occur.

Objective: The US Preventive Services Task Force (USPSTF) commissioned a systematic review to evaluate...

Keywords/Tags:
anxiety PPA preventive health screening Pregnancy

Screening for Depression and Suicide Risk in Adults US Preventive Services Task Force Recommendation Statement

Author/s: US Preventive Services Task Force, Barry, M. J., Nicholson, W. K., Silverstein, M., Chelmow, D., Coker, T. R., Davidson, K. W., Davis, E. M., Donahue, K. E., Jaén, C. R., Li, L., Ogedegbe, G., Pbert, L., Rao, G., Ruiz, J. M., Stevermer, J. J., Tsevat, J., Underwood, S. M., Wong, J. B.

IMPORTANCE Major depressive disorder (MDD), a common mental disorder in the US, may
have substantial impact on the lives of affected individuals. If left untreated, MDD can
interfere with daily functioning and can also be associated with an increased risk of
cardiovascular...

Keywords/Tags:
risk assessment depression suicide screening Adults

Effects of Tai Chi and Qigong on cognitive and physical functions in older adults: systematic review, meta-analysis, and meta-regression of randomized clinical trials

Author/s: Park, M., Song, R., Ju, K., Shin, J. C., Sea, J., Fan, X., Gao, X., Ryu, A., Li, Y.

Background: Older adults experience age-related declines in physical and cognitive functions due to interactions between aging and chronic diseases. Tai Chi and Qigong (TCQ) might be beneficial in improving the physical function and delaying the cognitive decline of this population. The...

Keywords/Tags:
cognitive function meta-analysis meta-regression Tai Chi qigong physical function

Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity

Author/s: Menegale, Francesco, Manica, Mattia, Zardini, Agnese, Guzzetta, Giorgio, Marziano, Valentina, d'Andrea, Valeria, Trentini, Filippo, Ajelli, Marco, Poletti, Piero, Merler, Stefano

Importance Estimates of the rate of waning of vaccine effectiveness (VE) against COVID-19 are key to assess population levels of protection and future needs for booster doses to face the resurgence of epidemic waves.

Objective To quantify the progressive waning of VE associated with the...

Keywords/Tags:
COVID-19 COVID-19 vaccine 'Vaccination

Diagnosis and management of depression in adolescents

Author/s: Korczak, D. J., Westwell-Roper, C., Sassi, R.

Depression is common among adolescents in Canada and has the potential to negatively affect long-term function and quality of life; despite this, in most affected adolescents depression remains undetected and untreated.

Management requires a multimodal approach, including risk assessment...

Keywords/Tags:
depression diagnosis and management adolescents adolescent psychiatry quality of life

Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes The GRADE Randomized Clinical Trial

Author/s: Wexler, D. J., de Boer, I. H., Ghosh, A., Younes, N., Bebu, I., Inzucchi, S. E., McGill, J. B., Mudaliar, S., Schade, D., Steffes, M., Tamborlane, W. V., Tan, M. H., Ismail-Beigi, F., GRADE Research Group

Importance: Type 2 diabetes (T2D) is the leading cause of kidney disease in the US. It is not known whether glucose-lowering medications differentially affect kidney function.

Objective: To evaluate kidney outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative...

Keywords/Tags:
Intention to Treat Analysis Albumins Creatinine diabetes, type 2 kidney function

Bedbugs

Author/s: Freedman, A., McDougall, L., Lamy, P.

A resurgence in bedbugs is a result of increased travel and insecticide resistance
Many bedbug populations are resistant to pyrethroid, a chemical contained in most currently used insecticides.1 Bedbugs multiply exponentially, with thousands of bugs per infestation after 2–3 months.
Keywords/Tags:
bedbugs insecticide resistance bedbug bites antihistamines anxiety

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