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Recent Resources

Use of Recommended Health Care Measures to Prevent Selected Complications of Sickle Cell Anemia in Children and Adolescents — Selected U.S. States, 2019

Author/s: Schieve, L. A., Simmons, G. M., Payne, A. B., Abe, K., Hsu, L. L., Hulihan, M., Pope, S., Rhie, S., Dupervil, B., Hooper, W. C.

Introduction: Sickle cell disease (SCD), a group of inherited blood cell disorders that primarily affects Black or African American persons, is associated with severe complications and a >20-year reduction in life expectancy. In 2014, an expert panel convened by the National Heart, Lung, and...

Keywords/Tags:
health personnel African Americans medicaid child blood cells

Weight Loss Outcomes Associated With Semaglutide Treatment for Patients With Overweight or Obesity

Author/s: Ghusn, W., De la Rosa, A., Sacoto, D.

Importance No retrospective cohort study has assessed the effectiveness of semaglutide at doses used in randomized clinical trials to treat obesity (ie, 1.7 and 2.4 mg).

Objective To study weight loss outcomes associated with semaglutide treatment at doses used in randomized clinical...

Keywords/Tags:
Cohort Studies overweight Retrospective Studies middle aged weight loss

Treatment of Clostridioides difficile Infection

Author/s: Sehgal, K., Cifu, A. S., Khanna, S.

Clostridioides difficile infection is a common nosocomial and community-acquired cause of diarrhea, with an estimated 453 000 cases per year in the United States.1 Treatment of CDI is based on severity and recurrence risk.
Keywords/Tags:
Humans United States Diarrhea C. diff infections

Diagnosis and Treatment of Myelodysplastic Syndromes: A Review

Author/s: Sekeres, M. A., Taylor, J.

Importance Myelodysplastic neoplasms (MDS), formerly known as myelodysplastic syndromes, are clonal hematopoietic malignancies that cause morphologic bone marrow dysplasia along with anemia, neutropenia, or thrombocytopenia. MDS are associated with an increased risk of acute myeloid leukemia (...

Keywords/Tags:
Leukemia Hematinics Prognosis Myedysplastic syndromes drug therapy

Pre-exposure prophylaxis for HIV: effective and underused

Author/s: Hempel, A., Biondi, M. J., Baril, J., Tan, D. H. S.

Pre-exposure prophylaxis (PrEP) is a highly effective modality for HIV prevention that can be prescribed by generalists.

Pre-exposure prophylaxis should be offered to patients who are at high risk of HIV exposure, including gay, bisexual and other men who have sex with men (GBM), women...

Keywords/Tags:
Follow-Up Studies Substance Abuse, intravenous Canada sexually transmitted diseases Drug users

Management of acute diverticulitis

Author/s: Zondervan, N., Snelgrove, R., Bradley, N.

1 Emergency department visits and hospital admissions for acute
diverticulitis have increased
Emergency department visits for acute diverticulitis increased by 26.8% to
113.9 visits per 100 000 from 2006 to 2013 in the United States.1
Hospital admissions for...

Keywords/Tags:
Colonoscopy abscess Anti-Bacterial Agents Bacterial translocation sepsis

2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

Author/s: Humbert, M., Kovacs, G., Hoeper, M. M., Badagliacca, R., Berger, R. M. F., Brida, M., Carlsen, J., Coats, A. J. S., Escribano-Subias, P., Ferrari, P., Ferreira, D. S., Ghofrani, H. A., Ginnakoulas, G., Kiely, D. G., Mayer, E., Meszaros, G., Nagavci, B., Olsson, K. M., Pepke-Zaba, J., Quint, J. K., Rådegran, G., Simonneau, G., Sitbon, O., Tonia, T., Toshner, M., Vachiery, J. L., Noordegraaf, A. V., Delcroix, M., Rosenkranz, S., ESC/ERS Scientific Document Group

Pulmonary hypertension (PH) is a pathophysiological disorder that may involve multiple clinical conditions and may be associated with a variety of cardiovascular and respiratory diseases. The complexity of managing PH requires a multifaceted, holistic, and multidisciplinary approach, with active...

Keywords/Tags:
Chronic Thrombo-embolic pulmonary hypertension clinical practice cardiovascular respiratory disease Pathophysiological disorder

2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

Author/s: Humbert, M., Kovacs, G., Hoeper, M. M., Badagliacca, R., Berger, R. M. F., Brida, M., Carlsen, J., Coats, A. J. S., Escribano-Subias, P., Ferrari, P., Ferreira, D. S., Ghofrani, H. A., Ginnakoulas, G., Kiely, D. G., Mayer, E., Meszaros, G., Nagavci, B., Olsson, K. M., Pepke-Zaba, J., Quint, J. K., Rådegran, G., Simonneau, G., Sitbon, O., Tonia, T., Toshner, M., Vachiery, J. L., Noordegraaf, A. V., Delcroix, M., Rosenkranz, S., ESC/ERS Scientific Document Group

Pulmonary hypertension (PH) is a pathophysiological disorder that may involve multiple clinical conditions and may be associated with a variety of cardiovascular and respiratory diseases. The complexity of managing PH requires a multifaceted, holistic, and multidisciplinary approach, with active...

Keywords/Tags:
Chronic Thrombo-embolic pulmonary hypertension clinical practice cardiovascular respiratory disease Pathophysiological disorder

International normalized ratio and activated partial thromboplastin time testing

Author/s: Chornenki, N. L. J., Fralick, M., Sholzberg, M.

International normalized ratio (INR) and activated partial thromboplastin time (aPTT) have limited clinical utility
The INR and aPTT should be used only for specific clinical indications (see Appendix 1, available at...

Keywords/Tags:
Bleeding disorder direct oral anticoagulants activated partial thromboplastin International normalized ratio Specimen handling

Optimal Urine Culture Diagnostic Stewardship Practice-Results from an Expert Modified-Delphi Procedure

Author/s: Claeys, K. C., Trautner, B. W., Leekha, S., Coffey, K. C., Crnich, C. J., Diekema, D. J., Fakih, M. G., Goetz, M. B., Gupta, K., Jones, M. M., Leykum, L., Liang, S. Y., Pineles, L., Pleiss, A., Spivak, E. S., Suda, K. J., Taylor, J. M., Rhee, C., Morgan, D. J.

Background: Urine cultures are nonspecific and often lead to misdiagnosis of urinary tract infection and unnecessary antibiotics. Diagnostic stewardship is a set of procedures that modifies test ordering, processing, and reporting in order to optimize diagnosis and downstream treatment. In this...

Keywords/Tags:
Diagnostic Stewardship Expert consensus modified Delphi urinary tract infections urine cultures

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