Opioids were involved in 42,249 deaths in the United States in 2016, and opioid overdoses have quintupled since 1999.1 Among the causes behind these statistics is increased opiate prescribing by physicians—with primary care providers accounting for about one half of opiate prescriptions.2 As a...
Recent Resources
Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients
BACKGROUND:
Angiotensin-converting-enzyme inhibitors improve the outcome among patients with left ventricular dysfunction, whether or not they have heart failure. We assessed the role of an angiotensin-converting-enzyme inhibitor, ramipril, in patients who were at high risk for...
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Noninvasive Nonpharmacological Treatment for Chronic Pain: Evidence Summary
Purpose of Review
To assess which noninvasive nonpharmacological treatments for common chronic pain conditions improve function and pain for at least 1 month after treatment.
Key Messages
• Interventions that improved function and/ or pain for at least 1 month when used for...
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Gabapentin for Chronic Neuropathic Pain in Adults
BACKGROUND:
Gabapentin is commonly used to treat neuropathic pain (pain due to nerve damage). This review updates a review published in 2014, and previous reviews published in 2011, 2005 and 2000.
OBJECTIVES:
To assess the analgesic efficacy and adverse effects of gabapentin...
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Amitriptyline for Neuropathic Pain in Adults
BACKGROUND:
This is an updated version of the original Cochrane review published in Issue 12, 2012. That review considered both fibromyalgia and neuropathic pain, but the effects of amitriptyline for fibromyalgia are now dealt with in a separate review.Amitriptyline is a tricyclic...
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CKD Guideline Recommendations for Primary Care
Leveraging Practice-Based Research Networks to Accelerate Implementation and Diffusion of Chronic Kidney Disease Guidelines in Primary Care Practices
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Short- and Long-Term Outcomes after Bariatric Surgery in the Medicare Population
Introduction. We conducted a technology assessment to summarize and appraise the current evidence regarding the effectiveness and safety of bariatric surgery in the Medicare-eligible population.
Data Sources. We searched six bibliographic databases and...
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Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement.
IMPORTANCE:
The number of deaths from cervical cancer in the United States has decreased substantially since the implementation of widespread cervical cancer screening and has declined from 2.8 to 2.3 deaths per 100 000 women from 2000 to 2015.
OBJECTIVE:
To update the US...
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Effects of Aspirin on Risks of Vascular Events and Cancer According to Bodyweight and Dose: Analysis of Individual Patient Data from Randomised Trials
BACKGROUND:
A one-dose-fits-all approach to use of aspirin has yielded only modest benefits in long-term prevention of cardiovascular events, possibly due to underdosing in patients of large body size and excess dosing in patients of small body size, which might also affect other outcomes...
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BTS Guidelines for the Management of Community Acquired Pneumonia in Adults: CURB-65
The British Thoracic Society (BTS) Guidelines for the management of Community Acquired Pneumonia (CAP) in Adults was published in December 2001 and superseded Guidelines published in 1993. A web-based update of the 2001 Guidelines was published in 2004. The 2004 Guidelines assessed relevant...
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