Importance Subclinical hypothyroidism is a common clinical entity among US adults associated in some studies with an increase in the risk of cardiovascular disease (CVD) and mortality. However, the extent to which CVD mediates the association between elevated serum thyrotropin...
Recent Resources
Comparative Effectiveness of Different Treatment Pathways for Opioid Use Disorder
IMPORTANCE:
Although clinical trials demonstrate the superior effectiveness of medication for opioid use disorder (MOUD) compared with nonpharmacologic treatment, national data on the comparative effectiveness of real-world treatment pathways are lacking.
OBJECTIVE:
To...
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What Parents Know Matters: Parental Knowledge at Birth Predicts Caregiving Behaviors at 9 Months
Objective
To examine the mediating role of socioeconomically disadvantaged parents' knowledge of early cognitive and language development at the first postpartum visit in the relation between education and caregiving behaviors at 9 months.
Study design
Parental knowledge was...
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What Parents Know Matters: Parental Knowledge at Birth Predicts Caregiving Behaviors at 9 Months
Objective
To examine the mediating role of socioeconomically disadvantaged parents' knowledge of early cognitive and language development at the first postpartum visit in the relation between education and caregiving behaviors at 9 months.
Study design
Parental knowledge was...
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Association between Age and Umbilical Hernia Repair Outcomes in Children: A Multistate Population-Based Cohort Study
OBJECTIVE:
To evaluate whether patient age or other sociodemographic and clinical characteristics are associated with recurrence or unplanned related hospital revisits after pediatric umbilical hernia repair.
STUDY DESIGN:
We performed a retrospective cohort study using the...
Use of anastrozole for breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial
BACKGROUND:
Two large clinical trials have shown a reduced rate of breast cancer development in high-risk women in the initial 5 years of follow-up after use of aromatase inhibitors (MAP.3 and International Breast Cancer Intervention Study II [IBIS-II]). Here, we report blinded long-term ...
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Alcohol Abstinence in Drinkers with Atrial Fibrillation
BACKGROUND:
Excessive alcohol consumption is associated with incident atrial fibrillation and adverse atrial remodeling; however, the effect of abstinence from alcohol on secondary prevention of atrial fibrillation is unclear.
METHODS:
We conducted a multicenter, prospective...
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Management of Heart Failure in 2019-2020, Part 1
Educational Objective
To understand the effects of sacubitril-valsartan vs enalapril on proximal aortic stiffness, cardiac remodeling, and cardiac contractile function among patients with heart failure with reduced ejection fraction (HFrEF).
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Association of household secondhand smoke exposure and mortality risk in patients with heart failure
BACKGROUND:
Secondhand smoke (SHS) exposure is a well-established cardiovascular risk factor, yet association between SHS and prognosis of heart failure remains uncertain.
METHOD:
Data were obtained from the US National Health and Nutrition Examination Surveys III from 1988...
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Association of E-Cigarette Use With Respiratory Disease Among Adults: A Longitudinal Analysis
INTRODUCTION:
E-cigarettes deliver an aerosol of nicotine by heating a liquid and are promoted as an alternative to combustible tobacco. This study determines the longitudinal associations between e-cigarette use and respiratory disease controlling for combustible tobacco use.
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