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Estimating Lifetime Benefits of Comprehensive Disease-Modifying Pharmacological Therapies in Patients With Heart Failure With Reduced Ejection Fraction: A Comparative Analysis of Three Randomised Controlled Trials

Author/s: Vaduganathan, M., Claggett, BL, Jhund, PS, Cunningham, JW, Ferreira, JP, Zannad, F, Packer, M, Fonarow, GC, McMurray, JJV, Solomon, S.D.

Background: Three drug classes (mineralocorticoid receptor antagonists [MRAs], angiotensin receptor-neprilysin inhibitors [ARNIs], and sodium/glucose cotransporter 2 [SGLT2] inhibitors) reduce mortality in patients with heart failure with reduced ejection fraction (HFrEF)...

Keywords/Tags:
CHF patients heart failure pharmacologic management

Aspirin for Primary Atherosclerotic Cardiovascular Disease Prevention as Baseline Risk Increases: A Meta-Regression Analysis

Author/s: Nudy, M, Cooper, J, Ghahramani, M, Ruzieh, M, Mandrola, J, Foy, AJ

Background

Aspirin is often prescribed for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) however, recent randomized trials (RCTs) have challenged this practice. Despite this, aspirin is commonly recommended for high risk primary prevention. We tested the...

Keywords/Tags:
aspirin primary prevention Atherosclerotic Cardiovascular Disease myocardial infarction Ischemic Stroke Major Bleeding

Evidenced-Based Pharmacotherapies for Alcohol Use Disorder

Author/s: Fairbanks, J, Umbreit, A, Kolla, BP, Karpyak, VM, Schneekloth, TD, Loukianova, LL, Sinha, S

Pathologic alcohol use affects more than 2 billion people and accounts for nearly 6% of all deaths worldwide. There are three medications approved for the treatment of alcohol use disorder by the US Food and Drug Administration (FDA): disulfiram, naltrexone (oral and long-acting injectable), and...

Keywords/Tags:
alcohol use disorder pharmacotherapy disulfiram naltrexone acamprosate anticonvulsants Baclofen

Secondhand Smoke Exposure and Subsequent Academic Performance Among U.S. Youth

Author/s: Choi, K., Chen-Sankey, J.C., Merianos, A.L., McGruder,C., Yerger, V.

Abstract

Introduction: Previous research shows the associations between secondhand smoke exposure and health consequences among youth, but less is known about its effect on academic performance. This study examines a dose-response relationship between secondhand smoke...

Secondhand Smoke Exposure and Subsequent Academic Performance Among U.S. Youth

Author/s: Choi, K., Chen-Sankey, J.C., Merianos, A.L., McGruder,C., Yerger, V.

Abstract

Introduction: Previous research shows the associations between secondhand smoke exposure and health consequences among youth, but less is known about its effect on academic performance. This study examines a dose-response relationship between secondhand smoke...

Clinical Practice Guideline: Ménière's Disease Executive Summary

Author/s: Basura, GJ, Adams, ME, Monfared, A, Schwartz, SR, Antonelli, PJ, Burkard, R, Bush, ML, Bykowski, J, Colandrea, M, Derebery, J, Kelly, EA, Kerber, KA, Koopman, CF, Kuch, AA, Marcolini, E, McKinnon, BJ, Ruckenstein, MJ, Valenzuela, CV, Vosooney,A, Walsh, SA, Nnacheta, LC, Dhepyasuwan, N, Buchanan, EM

OBJECTIVE:

Ménière's disease (MD) is a clinical condition defined by spontaneous vertigo attacks (each lasting 20 minutes to 12 hours) with documented low- to midfrequency sensorineural hearing loss in the affected ear before, during, or after one of the episodes of vertigo. It also...

Keywords/Tags:
Meniett device electrocochleography endolymphatic hydrops endolymphatic sac decompression fluctuating aural symptoms gentamicin labyrinthectomy sensorineural hearing loss sodium-restricted diet vestibular testing

Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19)

Author/s: Centers for Disease Control and Prevention (CDC)

The Centers for Disease Control and Prevention (CDC) is providing 1) background information on several cases of a recently reported multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19); and 2) a case definition for this syndrome. CDC...

Keywords/Tags:
COVID-19 Multisystem Inflammatory Syndrome children 2019 novel coronavirus 2019-nCOV

Preparing Nursing Homes and Assisted Living Facilities for Covid-19

Author/s: Long-term Care Team, Prevention and Response Brach Division of Healthcare Quality Promotion

Not available. 

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

Author/s: Martineau, AR, Jolliffe, DA, Hooper, RL, Greenberg, L, Aloia, JF, Bergman, P, Dubnov-Raz, G, Esposito, S, Ganmaa, D, Ginde, AA, Goodall, EC, Grant, CC, Griffiths, CJ, Janssens, W, Laaksi, I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson S Jr, Stelmach, I, Kumar, GT, Urashima, M", CA Jr

Objectives To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect.

Design Systematic review and meta-analysis of individual participant data (IPD) from...

Keywords/Tags:
vitamin D respiratory tract infections dietary supplements

Action Collaborative on Countering the U.S. Opioid Epidemic May 21 Public Virtual Symposium

Not available. 
Keywords/Tags:
opiods opiod misuse Opiod use disorder symposium

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