University of Oklahoma Health Sciences Center

diabetes mellitus

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Managing Adverse Effects of Incretin-Based Medications for Obesity

Author/s:

Robert F Kushner, Jaime P Almandoz, Domenica M Rubino

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This JAMA Insights explores optimal strategies for managing the adverse effects associated with incretin-based medications for obesity, including semaglutide and tirzepatide.

Keywords

Semaglutide tirzepatide Incretins diabetes mellitus type 2 diabetes Cardiovascular Diseases overweight

Acute and chronic neuropathies

Author/s:

Ginsberg, L.

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Peripheral nerve disorders are common and often treatable. The ‘default’ presentation of a polyneuropathy is a chronic, length- dependent, sensorimotor axonopathy. Recognizing deviations from this default, informed by the clinical features and investigations, can help identify the cause of a neuropathy in most cases. For inflamma- tory causes, such as GuillaineBarre syndrome and chronic inflamma- tory demyelinating polyradiculoneuropathy, there are effective immunomodulatory treatments. For other neuropathies, management consists of supportive care and treatment of the underlying cause, to prevent or limit progression.

Keywords

carpal tunnel syndrome chronic inflammatory demyelinating polyradiculoneuropathy diabetes mellitus Guillaine-Barre syndrome mononeuropathy Charcote-Mariee-Tooth disease polyneuropathy vasculitis nerve biopsy multifocal motor neuropathy