High quality evidence shows that vertebroplasty does not provide more clinically important benefits than placebo but may cause people harm.
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Omega-6 fats for the primary and secondary prevention of cardiovascular disease
BACKGROUND:
Omega-6 fats are polyunsaturated fats vital for many physiological functions, but their effect on cardiovascular disease (CVD) risk is debated.
OBJECTIVES:
To assess effects of increasing omega-6 fats (linoleic acid (LA), gamma-linolenic acid (GLA), dihomo-gamma-...
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Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update
Objective. To assess efficacy, comparative effectiveness, and harms of psychological and pharmacological treatments for adults with posttraumatic stress disorder (PTSD) and to update the original 2013 review.
Data sources. MEDLINE®, CINAHL®, Cochrane...
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Screening for Ovarian Cancer: US Preventive Services Task Force Recommendation Statement
IMPORTANCE:
With approximately 14 000 deaths per year, ovarian cancer is the fifth most common cause of cancer death among US women and the leading cause of death from gynecologic cancer. More than 95% of ovarian cancer deaths occur among women 45 years and older.
OBJECTIVE:
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Blood Pressure Targets for the Treatment of People with Hypertension and Cardiovascular Disease
BACKGROUND:
Hypertension is a prominent preventable cause of premature morbidity and mortality. People with hypertension and established cardiovascular disease are at particularly high risk, so reducing blood pressure below standard targets may be beneficial. This strategy could reduce...
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Different Durations of Corticosteroid therapy for Exacerbations of Chronic Obstructive Pulmonary Disease
BACKGROUND:
Current guidelines recommend that patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) should be treated with systemic corticosteroid for seven to 14 days. Intermittent systemic corticosteroid use is cumulatively associated with adverse effects...
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Nasal vs Oronasal CPAP for OSA Treatment: A Meta-Analysis.
BACKGROUND:
Nasal CPAP is the "gold standard" treatment for OSA. However, oronasal masks are frequently used in clinical practice. The aim of this study was to perform a meta-analysis of all randomized and nonrandomized trials that compared nasal vs oronasal masks on CPAP level, residual...
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Confronting Pain Management and the Opioid Epidemic: Balancing Societal and Individual Benefits and Risks of Prescription Opioid Use
The ongoing opioid crisis lies at the intersection of two substantial public health challenges—reducing the burden of suffering from pain and containing the rising toll of the harms that can result from the use of opioid medications. In March 2016, the U.S. Food and Drug Administration (FDA)...
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Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma
Objective. To assess efficacy of intermittent inhaled corticosteroid (ICS) therapy in different populations (0 to 4 years old with recurrent wheezing, 5 years and older with persistent asthma, with or without long-acting beta agonist [LABA]), and to assess efficacy of added long...
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Omega-3 Fatty Acids and Cardiovascular Disease: Current State of the Evidence
Focus of This Summary
This is a summary of a systematic review that evaluated the recent evidence regarding the effects of omega-3 fatty acids (FAs), primarily from marine oil supplements, on clinical and selected intermediate cardiovascular (CV) outcomes (i.e., blood pressure, lipid...
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