Abstract
Background
The effectiveness and safety of statins for the primary prevention of cardiovascular events and the extension of disability-free survival among older adults remain uncertain.
Methods
We conducted a double-blind, randomized, placebo-controlled trial at...
Recent Resources
Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults
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Pulmonary Nodules
Pulmonary nodules are classified as solid or subsolid, with subsolid nodules further classified as part-solid or pure ground-glass. Management strategies differ according to the type of nodule. A comparison of current and previous imaging studies, when available, is essential to assess the risk...
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Blood pressure measurement techniques
Do recommended blood pressure (BP) measurement techniques impact the accuracy of readings?
Cuff size, arm position, bladder distention, and leg crossing affect systolic BP (SBP) and diastolic BP (DBP) measurement accuracy (1 mm Hg lower to 20 mm Hg higher). Thin clothing does not impact...
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Rheumatoid Arthritis in Adults
Importance Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and destruction of cartilage and adjacent bone and can lead to irreversible disability. Rheumatoid arthritis affects 0.53% of adults worldwide and 0.74% of US adults.
Observations Rheumatoid...
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Narcolepsy
Narcolepsy is a chronic neurologic disorder that causes severe daytime sleepiness and impaired quality of life. Symptoms typically begin around age 10 to 20 years, yet diagnosis is often delayed for more than a decade.1 Narcolepsy is classified into narcolepsy type 1 (NT1; narcolepsy with...
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Astegolimab for chronic obstructive pulmonary disease with frequent exacerbations: pooled analysis of the ALIENTO and ARNASA trials
Rationale
The efficacy and safety of astegolimab, an anti-ST2 monoclonal antibody, was evaluated in participants with chronic obstructive pulmonary disease (COPD) and frequent exacerbations in the pivotal ALIENTO and ARNASA trials.
Objectives
To report the prespecified pooled...
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Primary Aldosteronism
Primary aldosteronism (PA) is an endocrine disorder that results from aldosterone overproduction by the adrenal glands, independent of physiological stimuli (hyperkalemia or renin). Symptomatic PA can cause hypertension and hypokalemia, but PA exists across a spectrum of severity from...
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Obesity Management Pharmacotherapies and Lifestyle Treatment for Pediatric Obesity Management A Systematic Review and Network Meta-Analysis
Abstract
Importance Pediatric obesity is a global health challenge. Although health behavior and lifestyle treatment (HBLT) is foundational, the comparative effectiveness of HBLT, various pharmacotherapies, and their combinations remains unclear.
Objective To compare the...
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Cervical Cancer Screening Updates—Focus on Self-Collected Primary Human Papillomavirus Testing
The incidence and mortality of cervical cancer have fallen since the adoption of widespread screening, but it still disproportionately affects underserved populations in the US. Expanding access to screening, especially in primary care settings, may reduce these disparities and improve women’s...
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Reliability of Physical Examination Findings in Youths Diagnosed With Pneumonia
Abstract
Importance Community-acquired pneumonia (CAP) accounts for nearly 2 million pediatric outpatient and 375 000 emergency department (ED) visits annually in the US. Guidelines recommend relying on physical examination findings, not imaging, to diagnose CAP in youths who can be...
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