Question: Are higher doses of buprenorphine treatment for opioid use disorder associated with improved retention in treatment when use of fentanyl (vs heroin) is more prevalent?
Findings: In this cohort study of 6499 patients initiating buprenorphine treatment between 2016 and 2020,...
Question: What outcomes are associated with ritonavir-boosted nirmatrelvir or molnupiravir use for outpatient treatment of SARS-CoV-2 Omicron subvariants, particularly BQ.1.1 and XBB.1.5, in high-risk individuals?
Findings: In a cohort study of 68 867 patients who received a diagnosis...
Alcohol-interactive medications pose increased risk of adverse events and death when used with alcohol.1 To our knowledge, the most recent study of alcohol use and alcohol-interactive medications included data through 2010.1 Mortality rates from alcohol and such medications have since increased....
Background: Atrial fibrillation (AF) has consistently been associated with a higher risk of incident dementia. Observational evidence has suggested catheter ablation may be associated with a lower risk of dementia in patients with AF, but further research is needed. The objectives of this study...
Importance: The effects of bempedoic acid on cardiovascular outcomes in statin-intolerant patients without a prior cardiovascular event (primary prevention) have not been fully described.
Objective: To determine the effects of bempedoic acid on cardiovascular outcomes in primary...
Importance: Type 2 diabetes (T2D) is the leading cause of kidney disease in the US. It is not known whether glucose-lowering medications differentially affect kidney function.
Objective: To evaluate kidney outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative...
Background: Interventions to reduce sexually transmitted infections (STIs) among men who have sex with men (MSM) are needed.
Methods: We conducted an open-label, randomized study involving MSM and transgender women who were taking preexposure prophylaxis (PrEP) against human...
Importance: Intranasal corticosteroids (INCs) remain the first-line treatment of chronic rhinosinusitis (CRS) in both adults and children, despite the lack of evidence regarding their efficacy in the pediatric population. Similarly, their effect on the sinonasal microbiome has not been well...
Background: There is a lack of real-life data regarding the frequency and predictive factors of hypoglycemia in older patients with type 2 diabetes (T2D). This study aimed to determine the frequency and predictors of hypoglycemia in older patients with insulin-treated T2D.
Methods: This...
Long-term patient-reported outcomes are needed to inform treatment decisions for localized prostate cancer.
METHODS
Patient-reported outcomes of 1643 randomly assigned participants in the ProtecT (Prostate Testing for Cancer and Treatment) trial were evaluated to assess the...
