Importance Restless legs syndrome (RLS) is a sleep-related movement disorder that affects approximately 3% of US adults to a clinically significant extent and can cause substantial sleep disturbance.
Observations Restless legs syndrome is characterized by an overwhelming urge to move...
Importance: Accurate assessment of intravascular volume facilitates management decisions about fluid management in patients with volume overload.
Objective: To identify the most accurate clinical examination, radiographic, and laboratory findings for assessing volume overload in...
Vulvar cancer is an underrecognized gynecologic malignant disease. The incidence of vulvar cancer is 2.3 per 100 000 people in Canada, and is increasing with the rising prevalence of human papillomavirus (HPV). More than 90% of vulvar cancers are squamous cell carcinomas (SCC), mostly diagnosed...
In the US, 23 million households rely on private wells for their drinking water, yet these wells are unregulated and unmonitored, and thus vulnerable to contamination. These exposures may lead to significant health consequences, including both acute manifestations and chronic disease. Primary...
Pertussis, or whooping cough, is a highly contagious respiratory illness caused by Bordetella pertussis, a fastidious gram-negative coccobacillus that is a human pathogen without known animal or environmental reservoirs. There are 8 additional known Bordetella species, 3 of which can cause...
Signs of physical abuse in pre-cruising infants are often overlooked
Sentinel injuries are minor, unexplained injuries in pre-cruising infants that are often the first indication of physical abuse, which may precede more serious harm. In one study, more than 25% of abused infants had had a...
Importance Type 1 diabetes is defined by hyperglycemia due to autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to insulin deficiency, and accounts for 5% to 10% of all cases of diabetes. Type 1 diabetes affects approximately 2 million people in the US and 8.4...
Background: Older adults often struggle to find footwear suitable for their clinical needs, thus affecting mobility, safety, and quality of life. Proper footwear is important due to fall risk, balance impairments, knee osteoarthritis (OA), hallux rigidus, plantar fasciitis, diabetic neuropathy,...
The AAP recommends vaccines to protect children against 18 diseases. The updated CDC schedule removed routine recommendations for hepatitis A and B, COVID-19, respiratory syncytial virus, rotavirus, influenza, and meningococcal disease, instead only recommending them for certain groups at high...
Clinical question
How effective are β-blockers and other first-line agents for essential tremor?
Bottom line
Older, small randomized controlled trials (RCTs) show that propranolol reduces tremor severity (about 2 points more than placebo on 10- to 15-point scales) and leads to...
