Allergic rhinitis affects approximately 1 in 6 adults, and chronic rhinosinusitis (CRS) affects approximately 1 in 8 adults in the US.1,2 Climate change, due in part to rising global temperatures secondary to release of carbon dioxide (CO2) and other greenhouse gases, is a growing public health...
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Should We Continue Anticoagulation Indefinitely after Catheter Ablation of Atrial Fibrillation?
Context
Current guidelines recommend indefinite anticoagulation after ablation of atrial fibrillation (AF) in patients with a CHA2DS2-VASc score ≥2–3, but few data support this practice. In a recent randomized trial (ALONE-AF), stopping anticoagulation 1 year after ablation did not raise...
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Reducing the risk of pet-associated zoonotic infections
Pet ownership can have health, emotional and social benefits; however, pets can serve as a source of zoonotic pathogens. One large, regional survey reported more than 75% of households having contact with a pet,1 and close, intimate interactions with pets (e.g., sleeping in beds with owners,...
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Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025–2026
Background: Changes in the vaccine advisory process in the United States have disrupted immunization guidance, which reinforces the need for independent evidence review to inform decisions regarding immunization for respiratory viruses during the 2025-2026 season.
Methods: We conducted a...
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What Is Ovarian Cancer?
Ovarian cancer is a malignancy of the ovary, the female reproductive organ that produces eggs.
How Common Is Ovarian Cancer?
Among women worldwide, ovarian cancer is the eighth most common malignancy and cause of cancer death. In 2022, ovarian cancer was diagnosed in about 325 000...
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Dense Breasts Are Common—Here Is What to Know
What Is Breast Density and How Common Are Dense Breasts?
Breast density refers to the amount of dense tissue (like glands and fibrous tissue) you have compared to fatty tissue in your breasts. Dense breasts are very common. About half of all women have them.
Why Does Breast Density...
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Colchicine for the secondary prevention of cardiovascular events
Rationale
People with cardiovascular disease are at risk of recurrent major adverse cardiovascular events, and chronic low‐grade inflammation may be a major underlying factor. Treatment with low‐dose colchicine has been proposed for the secondary prevention of cardiovascular events in...
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Therapeutic Use of Cannabis and Cannabinoids: A Review
Importance: Approximately 27% of adults in the US and Canada report having ever used cannabis for medical purposes. An estimated 10.5% of the US population reports using cannabidiol (CBD), a chemical compound extracted from cannabis that does not have psychoactive effects, for therapeutic...
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Open Access Canadian guideline on HIV pre- and postexposure prophylaxis: 2025 update
Background: New HIV infections occur annually in Canada, highlighting the need for pre- and postexposure prophylaxis (PrEP and PEP). Through the Canadian Institutes of Health Research (CIHR) Pan-Canadian Network for HIV/AIDS and STBBI (sexually transmitted and blood-borne infections) Clinical...
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Lung Cancer in Nonsmoking Individuals: A Review
Importance: Lung cancer in nonsmoking individuals (defined as people who have smoked fewer than 100 cigarettes in their lifetime) accounts for 15% to 20% of all lung cancer cases worldwide. In the US, the annual incidence of lung cancer in nonsmoking individuals is 14.4 to 20.8 per 100 000...
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