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Narcolepsy

Author/s: Kiran P. Maski, Thomas Scammell

Narcolepsy is a chronic neurologic disorder that causes severe daytime sleepiness and impaired quality of life. Symptoms typically begin around age 10 to 20 years, yet diagnosis is often delayed for more than a decade.1 Narcolepsy is classified into narcolepsy type 1 (NT1; narcolepsy with...

Keywords/Tags:
Narcolepsy brain hypothyroidism

Astegolimab for chronic obstructive pulmonary disease with frequent exacerbations: pooled analysis of the ALIENTO and ARNASA trials

Author/s: Jadwiga A Wedzicha, Alvar Agustí, Christopher E. Brightling, Peter Calverley, James D. Chalmers, Neil J. Greening, MeiLan K. Han, Divya Mohan, Julie Ng, Papi, Alberto, Nicolas Roche, Rebecca Saenz, Katerina Samara, Ruth Tal-Singer, Claus F. Vogelmeier, Xiaoying Yang, Bartolome R. Celli

Rationale
The efficacy and safety of astegolimab, an anti-ST2 monoclonal antibody, was evaluated in participants with chronic obstructive pulmonary disease (COPD) and frequent exacerbations in the pivotal ALIENTO and ARNASA trials.

Objectives
To report the prespecified pooled...

Keywords/Tags:
Astegolimab pulmonary disease chronic obstructive pulmonary disease ALIENTO trails ARNASA trials

Obesity Management Pharmacotherapies and Lifestyle Treatment for Pediatric Obesity Management A Systematic Review and Network Meta-Analysis

Author/s: Ke-wen Wan, Evander Fung-chau Lei, Ying Liu, Asefa Adimasu Taddese, Patrick lp, Gabriel Torbahn, Daniel Weghuber, Wendy Y. Huang, Bjorn T.Tam

Abstract
Importance Pediatric obesity is a global health challenge. Although health behavior and lifestyle treatment (HBLT) is foundational, the comparative effectiveness of HBLT, various pharmacotherapies, and their combinations remains unclear.

Objective To compare the...

Keywords/Tags:
pediatric obesity pharmacotherapy meta-analysis

Primary Aldosteronism

Author/s: Emily P. Marogi, Lisa Dubrofsky, Robert J. Weber

Primary aldosteronism (PA) is an endocrine disorder that results from aldosterone overproduction by the adrenal glands, independent of physiological stimuli (hyperkalemia or renin). Symptomatic PA can cause hypertension and hypokalemia, but PA exists across a spectrum of severity from...

Keywords/Tags:
primary aldosteronism Adrenal Glands Endocrinology

Cervical Cancer Screening Updates—Focus on Self-Collected Primary Human Papillomavirus Testing

Author/s: Hunter K. Holt, MD, MAS, Yasaswi Kislovskiy, MSc, George F Sawaya

The incidence and mortality of cervical cancer have fallen since the adoption of widespread screening, but it still disproportionately affects underserved populations in the US. Expanding access to screening, especially in primary care settings, may reduce these disparities and improve women’s...

Keywords/Tags:
cervical cancer Cervical Cancer Screening Papillomavirus Testing Screening Updates Women's Health

Reliability of Physical Examination Findings in Youths Diagnosed With Pneumonia

Author/s: Shubhada Hooli, Ron Reeder, Lauren Cutler, Laura F Sartori, Geoff Capraro, Amy Y. Cheng, Allison Cator, Matthew J. Lipshaw, Lilliam Ambroggio, Chris A. Rees, Son H. McLaren, Justin Moher, Leah Tzimenatos, Patrick S. Walsh, Chari D. Larsen, Richard M. Ruddy, Samir S. Shah, Nathan Kuppermann, Todd A. Florin

Abstract
Importance Community-acquired pneumonia (CAP) accounts for nearly 2 million pediatric outpatient and 375 000 emergency department (ED) visits annually in the US. Guidelines recommend relying on physical examination findings, not imaging, to diagnose CAP in youths who can be...

Keywords/Tags:
pneumonia youth Physical Examination

Lumbar Belt for Nonspecific Low Back Pain: A Randomized Clinical Trial

Author/s: Laurent Grange, Paul Calmels, Yves-Marie Pers, Guillaume Laustriat, Valerie Wieczorek, Nassima Saih, Mathieu De-Seze, Christelle Nguyen, Camille Daste, Isabelle Fayolle-Minon, Emmanuel Coudeyre, Francois Rannou

Importance Nonspecific low back pain is highly prevalent and disabling. Most current guidelines state that evidence is insufficient to recommend lumbar belts for this condition.

Objective To determine whether a soft and extensible lumbar belt reduces functional disability and pain in...

Keywords/Tags:
Nonspecific Low Back Pain Randomized Clinical Trial Adults

Management of Shoulder Pain in Primary Care: A Review

Author/s: Romi Haas, Thomas Ibounig, MD, Buchbinder, Rachelle

Importance Shoulder pain is a common and disabling condition most often managed in primary care. This review provides an evidence-based update on the diagnosis and management of shoulder pain to support clinical decision-making and improve patient outcomes.

Observations Shoulder pain...

Keywords/Tags:
Internal Medicine Internal Medicine Practice Shoulder Pain pain management primary care physical therapy

Diagnosis of Celiac Disease

Author/s: MD, Marisa G. Stahl, MSCS, Claire Jansson-Knodel

Celiac disease is an autoimmune disease that can occur through the lifespan and is characterized by immune-mediated enteropathy in response to dietary gluten.1 Celiac disease affects at least 1% of the global population. Important risk factors are a first-degree relative with celiac disease,...

Keywords/Tags:
celiac disease diagnosis health education serologic diagnosis

What Is Celiac Disease?

Author/s: Kristin L. Walter

Celiac disease is a chronic autoimmune disease caused by consumption of gluten in people with specific genetic markers. Celiac disease affects about 1% of people worldwide and people can start having symptoms at any age. Individuals at increased risk include those with a first-degree relative...

Keywords/Tags:
celiac disease patient education health education

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